PGGT1B

Across TCGA cell cohorts, PGGT1B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PGGT1B-associated genes across cancer lineages are VN1R3, RNASE8, and FAM205A. Each is linked with PGGT1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PGGT1B-to-partner and partner-to-PGGT1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R3 grouped by PGGT1B-low versus PGGT1B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGGT1B→partner) and Y-score (partner→PGGT1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	VN1R3 →	+0.033	+5.977	<.001	.001	3	1
LARGE_INTESTINE	RNASE8 →	+0.051	+3.930	<.001	.003	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1
CNS	SERPINA4 →	+0.020	+4.643	.002	.003	3	1
CNS	CCL21 →	+0.094	+5.044	<.001	.001	3	1
CNS	TEX55 →	+0.042	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

VN1R3 by PGGT1B expression — SOFT_TISSUE

Explore this box plot interactively →