PGGHG

Across TCGA cell cohorts, PGGHG mutation is significantly associated with the RNA expression of many other genes, with 145 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGGHG-associated genes across cancer lineages are RCVRN, CCR8, and OR1J2. Each is linked with PGGHG in more than 1 cancer types. Because this analysis shows association rather than direction, both PGGHG-to-partner and partner-to-PGGHG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCVRN grouped by PGGHG-low versus PGGHG-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGGHG→partner) and Y-score (partner→PGGHG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RCVRN →	+0.232	+3.544	.004	.003	3	2
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR1J2 →	+0.060	+4.635	<.001	.003	3	1
SOFT_TISSUE	BHLHA9 →	+0.027	+4.977	<.001	.002	3	1
SOFT_TISSUE	SERPINB11 →	+0.837	+4.222	<.001	.007	3	1
SOFT_TISSUE	GOLGA6L6 →	+0.009	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 145 associations by consensus.

RCVRN by PGGHG expression — BLOOD_Leukemia

Explore this box plot interactively →