PGD

Across TCGA pan-cancer cohorts, PGD mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PGD data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PGD mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PGD expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where PGD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.944	0.469	.003	32	view →
LUAD	DFS	Median	All	0.454	0.735	.004	30	view →
CCRCC	DFS	Median	II,III,IV	0.774	0.462	.011	10	view →
LSCC	DFS	Median	All	0.835	0.603	.009	10	view →
OV	DFS	Median	All	0.935	0.631	.024	4	view →
PDAC	OS	Tertile	IV	0.231	0.962	.024	3	view →
HNSC	DFS	Median	III,IV	0.727	0.525	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PGD–UCEC (DFS)

Open the UCEC breakdown →