PGD

Across TCGA pan-cancer cohorts, PGD RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PGD’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PGD RNA is repressed in tumor relative to normal tissue. In most cancer types PGD is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, COAD, and LIHC are the cancer types where PGD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PGD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.854	<.001	11	view →
COAD	Female	All	+0.918	<.001	10	view →
LIHC	Female	II,III,IV	+1.193	<.001	9	view →
KIRC	Male	II,III,IV	−0.759	<.001	9	view →
BLCA	Male	III,IV	+1.755	<.001	8	view →
LUSC	Male	II,III,IV	+1.301	<.001	7	view →
UCEC	All	III,IV	+2.410	<.001	6	view →
KIRP	All	II,III,IV	+0.785	.009	6	view →
KICH	Female	All	−0.724	<.001	6	view →
READ	All	All	+0.804	<.001	3	view →
LUAD	All	All	+0.403	.006	3	view →
CHOL	All	All	+1.519	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PGD–THCA

Open the THCA breakdown →