PGD

Across TCGA patient cohorts, PGD mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGD-associated genes across cancer lineages are MEK1, ASNS, and INPP4B. Each is linked with PGD in more than 1 cancer types. Because this analysis shows association rather than direction, both PGD-to-partner and partner-to-PGD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PGD-low versus PGD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGD→partner) and Y-score (partner→PGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.408	+3.169	.016	.019	3	2
UCEC	ASNS →	+0.452	+3.169	.007	.019	3	2
SKCM	INPP4B →	-0.186	-3.309	.036	.009	3	1
SKCM	XBP1 →	-0.268	-2.584	.018	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.117	-2.312	.044	.034	3	1
UCEC	FOXO3a →	+0.132	+1.887	.005	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MEK1 by PGD expression — UCEC

Explore this box plot interactively →