PGD

Across TCGA cell cohorts, PGD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,443 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PGD-associated GO terms across cancer lineages are DNA replication-dependent chromatin assembly, NADP+ metabolic process, and Quinone metabolic process. Each is linked with PGD in more than 11 cancer types. Because this analysis shows association rather than direction, both PGD-to-partner and partner-to-PGD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication-dependent chromatin assembly grouped by PGD-low versus PGD-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PGD→partner) and Y-score (partner→PGD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication-dependent chromatin assembly →	+0.179	+0.946	<.001	<.001	3	12
LUNG_NSCLC_LUSC	NADP+ metabolic process →	+0.139	+2.164	<.001	<.001	3	12
LUNG_SCLC	Quinone metabolic process →	+0.086	+0.823	.009	.006	3	11
LUNG_NSCLC_LUAD	Ketone metabolic process →	+0.122	+1.704	<.001	<.001	3	10
LARGE_INTESTINE	Nucleotide biosynthetic process →	+0.046	+1.047	<.001	<.001	3	10
BONE	Regulation of DNA stability →	+0.134	+0.889	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,443 associations by consensus.

DNA replication-dependent chromatin assembly by PGD expression — BONE

Explore this box plot interactively →