PGC

Across TCGA patient cohorts, PGC RNA expression is significantly associated with the RNA expression of many other genes, with 11,383 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible PGC-associated genes across cancer lineages are TSPAN8, SLC34A2, and CLDN2. Each is linked with PGC in more than 12 cancer types. Because this analysis shows association rather than direction, both PGC-to-partner and partner-to-PGC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PGC versus TSPAN8 in ESCA, with a Pearson correlation of 0.59.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGC→partner) and Y-score (partner→PGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	TSPAN8 →	+4.371	+4.674	<.001	<.001	3	13
LUSC	SLC34A2 →	+3.576	+3.153	<.001	<.001	3	13
ESCA	CLDN2 →	+2.539	+4.283	<.001	<.001	3	13
SCLC	SFTPA2 →	+6.201	+2.822	<.001	<.001	3	12
ESCA	SPDEF →	+2.554	+4.198	<.001	<.001	3	12
ESCA	SPINK1 →	+4.236	+4.689	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,383 associations by consensus.

PGC vs TSPAN8 — ESCA

Explore this scatter interactively →