PGC

Across TCGA cell cohorts, PGC mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PGC-associated genes across cancer lineages are CHRNB3, IFNA6, and CCL19. Each is linked with PGC in more than 1 cancer types. Because this analysis shows association rather than direction, both PGC-to-partner and partner-to-PGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNB3 grouped by PGC-low versus PGC-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGC→partner) and Y-score (partner→PGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	IFNA6 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.139	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR8D4 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	ASCL4 →	+0.013	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MLN →	+0.118	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CHRNB3 by PGC expression — SKIN

Explore this box plot interactively →