PGAP3

Across TCGA patient cohorts, PGAP3 mutation is significantly associated with the RNA expression of many other genes, with 855 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAP3-associated genes across cancer lineages are RNU6-752P, RNU6-399P, and RNA5SP408. Each is linked with PGAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGAP3-to-partner and partner-to-PGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-752P grouped by PGAP3-low versus PGAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP3→partner) and Y-score (partner→PGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-752P →	+0.294	+2.572	<.001	.007	3	3
HNSC	RNU6-399P →	+0.341	+5.655	<.001	.004	3	2
UCEC	RNA5SP408 →	+0.370	+2.727	<.001	.005	3	2
HNSC	GCSHP1 →	+0.207	+6.111	<.001	.002	3	2
SKCM	SALL4P2 →	+0.023	+4.436	<.001	.001	3	1
HNSC	ANKRD60 →	+0.122	+5.303	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 855 associations by consensus.

RNU6-752P by PGAP3 expression — UCEC

Explore this box plot interactively →