PGAP3

Across TCGA pan-cancer cohorts, PGAP3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PGAP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PGAP3 RNA is repressed in tumor relative to normal tissue. In most cancer types PGAP3 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, STAD, and BRCA are the cancer types where PGAP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PGAP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−1.589	<.001	11	view →
STAD	Male	All	+0.900	.004	6	view →
BRCA	All	All	+0.525	<.001	6	view →
LUSC	Male	All	−0.364	<.001	6	view →
KIRC	All	II,III,IV	−0.350	.003	6	view →
COAD	All	II,III,IV	−0.464	.001	4	view →
KIRP	All	All	−0.352	.002	4	view →
CHOL	All	II,III,IV	+1.025	.042	2	view →
LIHC	All	All	+0.319	.002	2	view →
HNSC	All	II,III,IV	−0.309	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PGAP3–KICH

Open the KICH breakdown →