PGAP3

Across TCGA patient cohorts, PGAP3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAP3-associated genes across cancer lineages are ACC_pS79, G6PD, and GSK-3a-b_pS21_S9. Each is linked with PGAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP3-to-partner and partner-to-PGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by PGAP3-low versus PGAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP3→partner) and Y-score (partner→PGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.413	+3.009	.013	.019	3	1
UCEC	G6PD →	-0.375	-3.584	.016	.002	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.578	+2.459	.005	.020	3	1
UCEC	Heregulin →	-0.160	-3.000	.007	.036	3	1
UCEC	JNK2 →	+0.240	+2.834	.012	.034	3	1
UCEC	MAPK_pT202_Y204 →	+0.569	+2.820	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ACC_pS79 by PGAP3 expression — UCEC

Explore this box plot interactively →