PGAP3

Across TCGA cell cohorts, PGAP3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGAP3-associated genes across cancer lineages are TMSB4Y, DEFA4, and OR1F1. Each is linked with PGAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP3-to-partner and partner-to-PGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMSB4Y grouped by PGAP3-low versus PGAP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP3→partner) and Y-score (partner→PGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMSB4Y →	+1.789	+3.556	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR1F1 →	+0.298	+3.658	.001	.005	3	1
LARGE_INTESTINE	BPIFA1 →	+0.134	+3.688	.001	.002	3	1
LARGE_INTESTINE	ACSM6 →	+0.019	+3.658	.002	.005	2	1
BLOOD_Leukemia	SOX1 →	+0.624	+4.149	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TMSB4Y by PGAP3 expression — LARGE_INTESTINE

Explore this box plot interactively →