PGAP2

Across TCGA patient cohorts, PGAP2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAP2-associated genes across cancer lineages are PDCD4, Ku80, and MEK1. Each is linked with PGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP2-to-partner and partner-to-PGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PGAP2-low versus PGAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP2→partner) and Y-score (partner→PGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.584	-2.807	.004	.003	3	2
UCEC	Ku80 →	+0.333	+2.820	.001	.001	3	1
UCEC	MEK1 →	+0.514	+3.584	.001	.002	3	1
UCEC	Notch1 →	+0.147	+2.179	.017	.034	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.593	-3.169	.002	.018	3	1
UCEC	p62 Lck ligand →	+0.462	+3.594	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PDCD4 by PGAP2 expression — UCEC

Explore this box plot interactively →