PGAP2

Across TCGA cell cohorts, PGAP2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGAP2-associated genes across cancer lineages are NKX2-6, KCNA4, and TLE7. Each is linked with PGAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAP2-to-partner and partner-to-PGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by PGAP2-low versus PGAP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP2→partner) and Y-score (partner→PGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KCNA4 →	+0.028	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	ASPN →	+0.048	+3.648	<.001	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.383	+3.252	<.001	.009	3	1
LARGE_INTESTINE	ADAMTS19 →	+0.720	+3.541	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

NKX2-6 by PGAP2 expression — BLOOD_Leukemia

Explore this box plot interactively →