PGAP2

Across TCGA cell cohorts, PGAP2 mutation is significantly associated with the mutation status of many other genes, with 4,390 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGAP2-associated genes across cancer lineages are LMF2, AP1B1, and TCFL5. Each is linked with PGAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PGAP2-to-partner and partner-to-PGAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMF2 grouped by PGAP2-low versus PGAP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAP2→partner) and Y-score (partner→PGAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LMF2 →	+3.202	+4.282	<.001	<.001	1	3
BLOOD_Leukemia	AP1B1 →	+4.050	+4.820	<.001	<.001	1	3
LARGE_INTESTINE	TCFL5 →	+4.000	+3.459	<.001	<.001	1	3
BLOOD_Leukemia	ANGPT4 →	+3.635	+3.635	.003	.003	1	3
LARGE_INTESTINE	CCDC9 →	+3.263	+4.056	<.001	<.001	1	3
BLOOD_Leukemia	TAF6 →	+3.465	+3.913	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,390 associations by consensus.

LMF2 by PGAP2 expression — BLOOD_Leukemia

Explore this box plot interactively →