PGAM5

Across TCGA pan-cancer cohorts, PGAM5 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PGAM5 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher PGAM5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PGAM5 expression acts as an unfavorable survival marker.

READ and SKCM are the cancer types where PGAM5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	III,IV	0.255	0.757	.008	9	view →
SKCM	DFS	Median	All	0.058	0.757	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PGAM5–READ (DFS)

Open the READ breakdown →