PGAM5

Across TCGA pan-cancer cohorts, PGAM5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PGAM5 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PGAM5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PGAM5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and PDAC are the cancer types where PGAM5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.433	.007	32	view →
LSCC	DFS	Median	II,III,IV	0.845	0.554	.004	28	view →
PDAC	DFS	Quartile	II,III,IV	0.483	0.201	.003	23	view →
LUAD	DFS	Tertile	III,IV	0.995	0.311	.001	15	view →
CCRCC	DFS	Quartile	III,IV	0.229	0.695	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PGAM5–UCEC (OS)

Open the UCEC breakdown →