PGAM5

Across TCGA patient cohorts, PGAM5 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PGAM5-associated genes across cancer lineages are FOXO3a, JNK_pT183_Y185, and Rab25. Each is linked with PGAM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAM5-to-partner and partner-to-PGAM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by PGAM5-low versus PGAM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM5→partner) and Y-score (partner→PGAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.118	-2.292	.016	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.169	-2.446	.038	.020	3	1
UCEC	Rab25 →	-0.487	-2.459	.002	.020	2	1
UCEC	Caspase-8 →	-0.290	-3.169	.016	.019	2	1
UCEC	VHL →	-1.176	-2.459	<.001	.020	1	1
UCEC	Caspase-7-cleavedD198 →	+0.941	+2.459	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FOXO3a by PGAM5 expression — UCEC

Explore this box plot interactively →