Across TCGA cell cohorts, PGAM4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PGAM4-associated genes across cancer lineages are MS4A4A, MSGN1, and TAFA1. Each is linked with PGAM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGAM4-to-partner and partner-to-PGAM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGAM4→partner) and Y-score (partner→PGAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.219	+3.678	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.213	+4.155	<.001	.003	3	1
LARGE_INTESTINE	RNF212B →	+0.146	+3.678	<.001	.009	3	1
LUNG_NSCLC_LUAD	PNLIPRP3 →	+0.842	+4.442	<.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

PGAM4 survival (RNA) · tumor vs normal (RNA) · all PGAM4 data types