PGA5

Across TCGA patient cohorts, PGA5 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PGA5-associated genes across cancer lineages are NENFP2, FAM224A, and MIR6792. Each is linked with PGA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PGA5-to-partner and partner-to-PGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NENFP2 grouped by PGA5-low versus PGA5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PGA5→partner) and Y-score (partner→PGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NENFP2 →	+0.395	+5.145	<.001	.007	3	2
LUAD	FAM224A →	+0.047	+5.099	<.001	.008	3	2
BRCA	MIR6792 →	+0.626	+4.971	<.001	.005	3	1
UCEC	RNU6-1318P →	+0.459	+4.358	<.001	.001	3	1
UCEC	MIR548O →	+0.736	+3.581	<.001	.004	3	1
UCEC	LINC01201 →	+0.099	+4.335	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

NENFP2 by PGA5 expression — COAD

Explore this box plot interactively →