Across TCGA patient cohorts, PFN3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible PFN3-associated genes across cancer lineages are RNU6-1107P, RNU6-806P, and MTCO2P31. Each is linked with PFN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFN3-to-partner and partner-to-PFN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN3→partner) and Y-score (partner→PFN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1107P →	+0.419	+4.984	<.001	.009	3	1
LUSC	RNU6-806P →	+0.708	+6.081	<.001	.002	3	1
LUSC	MTCO2P31 →	+0.141	+5.038	<.001	.009	3	1
LUSC	MTND3P20 →	+0.243	+6.906	<.001	<.001	3	1
LUSC	RN7SKP263 →	+0.147	+6.309	.005	.001	3	1
LUSC	RN7SL645P →	+0.161	+5.038	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

PFN3 survival (RNA) · tumor vs normal (RNA) · all PFN3 data types