PFN2

Across TCGA patient cohorts, PFN2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFN2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and EGFR. Each is linked with PFN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFN2-to-partner and partner-to-PFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PFN2-low versus PFN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN2→partner) and Y-score (partner→PFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.092	-1.794	.027	.027	3	1
UCEC	EGFR_pY1068 →	-0.236	-2.321	.022	.006	3	1
UCEC	EGFR →	-0.158	-2.459	.016	.019	3	1
UCEC	eIF4E →	+0.197	+2.321	.023	.006	3	1
UCEC	ACC1 →	+0.390	+1.750	.009	.049	3	1
UCEC	HER2_pY1248 →	-0.226	-2.321	.040	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

14-3-3_beta by PFN2 expression — UCEC

Explore this box plot interactively →