PFN2

Across TCGA pan-cancer cohorts, PFN2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PFN2 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PFN2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PFN2 expression acts as an unfavorable survival marker, although some lineages such as LGG and CHOL show a favorable association.

HNSC, UCEC, and SCLC are the cancer types where PFN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.582	0.740	<.001	101	view →
UCEC	DFS	Median	All	0.581	0.711	<.001	68	view →
SCLC	DFS	Median	III,IV	0.226	0.542	.003	58	view →
LUAD	DFS	Median	All	0.598	0.754	.002	49	view →
LIHC	OS	Quartile	All	0.366	0.624	<.001	45	view →
STAD	DFS	Median	IV	0.141	0.655	.011	43	view →
LGG	DFS	Median	All	0.804	0.667	<.001	37	view →
MESO	OS	Tertile	III,IV	0.480	0.774	.002	35	view →
ACC	DFS	Median	All	0.291	0.606	.001	30	view →
READ	DFS	Tertile	IV	0.317	0.827	.003	28	view →
COAD	DFS	Median	II,III,IV	0.414	0.651	.002	27	view →
SARC	OS	Tertile	All	0.404	0.671	<.001	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PFN2–HNSC (OS)

Open the HNSC breakdown →