PFN2

Across TCGA cell cohorts, PFN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,752 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PFN2-associated GO terms across cancer lineages are Spindle assembly, Positive regulation of skeletal muscle fiber development, and Chloride transport. Each is linked with PFN2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PFN2-to-partner and partner-to-PFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle assembly grouped by PFN2-low versus PFN2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFN2→partner) and Y-score (partner→PFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Spindle assembly →	+0.065	+1.848	.002	.002	3	9
LIVER	Positive regulation of skeletal muscle fiber development →	+1.626	+0.908	.002	.007	3	8
PANCREAS	Chloride transport →	-0.044	-1.305	.001	.002	2	9
STOMACH	Mitotic nuclear division →	+0.081	+2.396	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Chromosomal DNA methylation maintenance following DNA replication →	+0.144	+1.391	<.001	.001	3	8
PANCREAS	Positive regulation of mitotic cell cycle →	+0.062	+1.577	.002	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,752 associations by consensus.

Spindle assembly by PFN2 expression — PANCREAS

Explore this box plot interactively →