PFKM

Across TCGA patient cohorts, PFKM mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKM-associated genes across cancer lineages are ERK2, PDK1_pS241, and PDK1. Each is linked with PFKM in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKM-to-partner and partner-to-PFKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PFKM-low versus PFKM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKM→partner) and Y-score (partner→PFKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.196	+3.807	.002	<.001	3	2
UCEC	PDK1_pS241 →	+0.145	+1.847	.010	.007	3	2
UCEC	PDK1 →	+0.077	+2.920	.030	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.129	-1.575	.001	.017	3	2
UCEC	Rab25 →	-0.308	-1.874	.004	.049	3	2
UCEC	Annexin-1 →	+0.535	+2.107	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ERK2 by PFKM expression — UCEC

Explore this box plot interactively →