PFKM

Across TCGA cell cohorts, PFKM RNA expression is significantly associated with the go_rna of many other GO terms, with 5,192 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PFKM-associated GO terms across cancer lineages are Fructose 1,6-bisphosphate metabolic process, Canonical glycolysis, and Glucose catabolic process to pyruvate. Each is linked with PFKM in more than 17 cancer types. Because this analysis shows association rather than direction, both PFKM-to-partner and partner-to-PFKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fructose 1,6-bisphosphate metabolic process grouped by PFKM-low versus PFKM-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKM→partner) and Y-score (partner→PFKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Fructose 1,6-bisphosphate metabolic process →	+0.214	+1.527	<.001	<.001	3	18
STOMACH	Canonical glycolysis →	+0.146	+1.175	<.001	<.001	3	15
STOMACH	Glucose catabolic process to pyruvate →	+0.146	+1.175	<.001	<.001	3	15
STOMACH	Glucose catabolic process →	+0.133	+0.933	<.001	<.001	3	14
LUNG_NSCLC_LUAD	Defense response to bacterium →	-0.093	-1.022	<.001	.002	3	12
STOMACH	Glycolytic process through fructose-6-phosphate →	+0.139	+0.916	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,192 associations by consensus.

Fructose 1,6-bisphosphate metabolic process by PFKM expression — URINARY_TRACT

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