PFKFB4

Across TCGA patient cohorts, PFKFB4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,945 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB4-associated genes across cancer lineages are HILPDA, BNIP3, and ENO2. Each is linked with PFKFB4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PFKFB4-to-partner and partner-to-PFKFB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFKFB4 versus HILPDA in GBM, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB4→partner) and Y-score (partner→PFKFB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HILPDA →	+1.157	+0.375	<.001	<.001	3	6
LSCC	BNIP3 →	+0.919	+0.241	.001	.004	3	5
LSCC	ENO2 →	+1.160	+0.320	<.001	.001	3	5
LSCC	PPFIA4 →	+1.107	+0.296	<.001	.001	3	5
UCEC	ERO1A →	+0.821	+0.373	.002	.002	3	5
HNSC	CDH20 →	-0.557	-0.427	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,945 associations by consensus.

PFKFB4 vs HILPDA — GBM

Explore this scatter interactively →