PFKFB4

Across TCGA pan-cancer cohorts, PFKFB4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PFKFB4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PFKFB4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PFKFB4 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BLCA, KIRC, and KIRP are the cancer types where PFKFB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PFKFB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+2.602	<.001	12	view →
KIRC	Male	All	+2.182	<.001	12	view →
KIRP	All	II,III,IV	+1.063	<.001	10	view →
HNSC	Male	All	+0.980	<.001	10	view →
LIHC	Female	II,III,IV	+1.114	<.001	9	view →
COAD	Male	IV	+1.424	<.001	8	view →
UCEC	All	III,IV	+2.673	<.001	6	view →
KICH	Female	II,III,IV	−1.239	<.001	6	view →
BRCA	All	III,IV	+0.973	<.001	6	view →
LUSC	All	All	+0.803	<.001	6	view →
CHOL	All	All	+1.192	<.001	5	view →
LUAD	All	All	+0.351	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PFKFB4–BLCA

Open the BLCA breakdown →