PFKFB4

Across TCGA patient cohorts, PFKFB4 mutation is significantly associated with the RNA expression of many other genes, with 975 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB4-associated genes across cancer lineages are SNORD111B, FEN1, and PC. Each is linked with PFKFB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB4-to-partner and partner-to-PFKFB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD111B grouped by PFKFB4-low versus PFKFB4-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB4→partner) and Y-score (partner→PFKFB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNORD111B →	+0.600	+4.969	<.001	.009	3	2
UCEC	FEN1 →	+0.562	+2.700	.008	.006	3	2
UCEC	PC →	+0.691	+3.721	<.001	<.001	3	2
UCEC	TIPIN →	+0.452	+2.523	.002	.001	3	2
SKCM	NAP1L4 →	+0.484	+3.516	.006	.002	3	2
UCEC	DHRS2 →	+0.985	+2.772	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 975 associations by consensus.

SNORD111B by PFKFB4 expression — GBM

Explore this box plot interactively →