PFKFB4

Across TCGA patient cohorts, PFKFB4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB4-associated genes across cancer lineages are INPP4B, JNK_pT183_Y185, and JNK2. Each is linked with PFKFB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB4-to-partner and partner-to-PFKFB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by PFKFB4-low versus PFKFB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB4→partner) and Y-score (partner→PFKFB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.284	-3.169	.044	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-3.169	.007	.018	3	1
UCEC	JNK2 →	+0.194	+2.115	.025	.019	3	1
UCEC	MEK1 →	+0.503	+2.807	.001	.003	3	1
UCEC	MSH2 →	-0.281	-3.143	.005	.018	3	1
UCEC	mTOR →	-0.215	-2.321	.002	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

INPP4B by PFKFB4 expression — UCEC

Explore this box plot interactively →