PFKFB4

Across TCGA cell cohorts, PFKFB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,675 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PFKFB4-associated GO terms across cancer lineages are Fructose 2,6-bisphosphate metabolic process, Glycolytic process through fructose-6-phosphate, and Glycolytic process through glucose-6-phosphate. Each is linked with PFKFB4 in more than 13 cancer types. Because this analysis shows association rather than direction, both PFKFB4-to-partner and partner-to-PFKFB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fructose 2,6-bisphosphate metabolic process grouped by PFKFB4-low versus PFKFB4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB4→partner) and Y-score (partner→PFKFB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Fructose 2,6-bisphosphate metabolic process →	+0.501	+1.724	<.001	<.001	3	13
BLOOD_Myeloma	Glycolytic process through fructose-6-phosphate →	+0.137	+2.223	.002	.004	2	14
BLOOD_Myeloma	Glycolytic process through glucose-6-phosphate →	+0.137	+2.223	.002	.004	2	14
BLOOD_Myeloma	Glucose catabolic process →	+0.124	+1.727	.001	.008	2	13
CNS	Nucleoside diphosphate catabolic process →	+0.111	+1.276	<.001	.001	3	11
CNS	Purine nucleoside diphosphate catabolic process →	+0.105	+1.269	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,675 associations by consensus.

Fructose 2,6-bisphosphate metabolic process by PFKFB4 expression — BLOOD_Leukemia

Explore this box plot interactively →