PFKFB4

Across TCGA cell cohorts, PFKFB4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PFKFB4-associated genes across cancer lineages are MAGEB4, MS4A7, and RAX2. Each is linked with PFKFB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB4-to-partner and partner-to-PFKFB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PFKFB4-low versus PFKFB4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB4→partner) and Y-score (partner→PFKFB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	MS4A7 →	+0.029	+3.464	.009	.004	3	1
LARGE_INTESTINE	RAX2 →	+0.060	+2.933	.001	.003	3	1
LARGE_INTESTINE	OR10Q1 →	+0.122	+2.657	<.001	.007	3	1
LARGE_INTESTINE	HMX3 →	+0.511	+3.531	.001	.007	3	1
LARGE_INTESTINE	TMC3 →	+0.044	+3.321	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAGEB4 by PFKFB4 expression — LARGE_INTESTINE

Explore this box plot interactively →