PFKFB2

Across TCGA patient cohorts, PFKFB2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,092 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PFKFB2-associated genes across cancer lineages are PPP2R5A, ARV1, and C1orf116. Each is linked with PFKFB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PFKFB2-to-partner and partner-to-PFKFB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PFKFB2 versus PPP2R5A in LUAD, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB2→partner) and Y-score (partner→PFKFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPP2R5A →	+0.574	+0.402	<.001	<.001	3	5
LUAD	ARV1 →	+0.608	+0.457	<.001	<.001	3	5
BRCA	C1orf116 →	+1.279	+0.466	<.001	<.001	3	5
OV	SLC50A1 →	+0.590	+0.310	.001	.002	3	4
GBM	C1orf198 →	+0.932	+0.577	<.001	<.001	3	4
UCEC	PPP1R1B →	+1.905	+0.768	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,092 associations by consensus.

PFKFB2 vs PPP2R5A — LUAD

Explore this scatter interactively →