PFKFB2

Across TCGA pan-cancer cohorts, PFKFB2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PFKFB2 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher PFKFB2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PFKFB2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and UVM show a favorable association.

ESCA, LIHC, and OV are the cancer types where PFKFB2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	All	0.307	1.000	.003	36	view →
LIHC	OS	Median	All	0.714	0.833	.002	32	view →
OV	OS	Quartile	III,IV	0.792	0.868	.014	30	view →
LGG	OS	Tertile	All	0.285	0.586	<.001	24	view →
LUSC	OS	Tertile	III,IV	0.565	0.807	.008	23	view →
UCEC	DFS	Median	III,IV	0.699	0.465	.010	16	view →
UVM	DFS	Tertile	All	0.882	0.618	.015	15	view →
BLCA	OS	Quartile	II,III,IV	0.487	0.654	.023	14	view →
STAD	DFS	Tertile	IV	0.145	0.650	.005	12	view →
HNSC	DFS	Tertile	IV	0.499	0.194	.018	10	view →
COAD	DFS	Tertile	IV	0.602	0.316	.020	9	view →
SARC	OS	Quartile	All	0.809	0.606	.033	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PFKFB2–ESCA (OS)

Open the ESCA breakdown →