PFKFB2

Across TCGA patient cohorts, PFKFB2 mutation is significantly associated with the RNA expression of many other genes, with 1,645 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB2-associated genes across cancer lineages are PUSL1, CUEDC1, and ZNF511. Each is linked with PFKFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB2-to-partner and partner-to-PFKFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PUSL1 grouped by PFKFB2-low versus PFKFB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB2→partner) and Y-score (partner→PFKFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PUSL1 →	+0.636	+3.465	.001	.003	3	2
UCEC	CUEDC1 →	+0.656	+2.244	<.001	<.001	3	2
SKCM	ZNF511 →	+0.501	+3.516	.001	.002	3	2
SKCM	RPS8P10 →	+0.067	+2.518	.003	.003	3	2
UCEC	PARD6A →	+0.757	+2.201	<.001	<.001	3	2
UCEC	KXD1 →	+0.413	+2.233	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,645 associations by consensus.

PUSL1 by PFKFB2 expression — SKCM

Explore this box plot interactively →