PFKFB2

Across TCGA patient cohorts, PFKFB2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PFKFB2-associated genes across cancer lineages are EGFR_pY1068, 14-3-3_beta, and A-Raf_pS299. Each is linked with PFKFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB2-to-partner and partner-to-PFKFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PFKFB2-low versus PFKFB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB2→partner) and Y-score (partner→PFKFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.344	-3.584	<.001	.002	3	2
UCEC	14-3-3_beta →	-0.104	-2.558	.008	.010	3	1
UCEC	A-Raf_pS299 →	-0.124	-2.000	.007	.010	3	1
UCEC	ERK2 →	+0.224	+1.874	.003	.049	3	1
UCEC	GATA6 →	-0.195	-3.307	.002	.009	3	1
UCEC	INPP4B →	-0.328	-2.584	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

EGFR_pY1068 by PFKFB2 expression — UCEC

Explore this box plot interactively →