PFKFB2

Across TCGA cell cohorts, PFKFB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,232 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PFKFB2-associated GO terms across cancer lineages are Glycerolipid biosynthetic process, Endosomal lumen acidification, and Glycerophospholipid biosynthetic process. Each is linked with PFKFB2 in more than 11 cancer types. Because this analysis shows association rather than direction, both PFKFB2-to-partner and partner-to-PFKFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerolipid biosynthetic process grouped by PFKFB2-low versus PFKFB2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB2→partner) and Y-score (partner→PFKFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Glycerolipid biosynthetic process →	+0.027	+0.556	.002	.001	3	12
KIDNEY	Endosomal lumen acidification →	+0.155	+1.278	.001	.005	3	11
CNS	Glycerophospholipid biosynthetic process →	+0.032	+0.662	.004	.002	3	11
KIDNEY	Endosome organization →	+0.055	+0.985	.005	.003	2	12
LUNG_SCLC	Macroautophagy →	+0.049	+1.402	<.001	.001	3	10
SOFT_TISSUE	Glycerophospholipid metabolic process →	+0.027	+1.190	<.001	.002	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,232 associations by consensus.

Glycerolipid biosynthetic process by PFKFB2 expression — CNS

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