PFKFB2

Across TCGA cell cohorts, PFKFB2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PFKFB2-associated genes across cancer lineages are C5orf49, CCT4, and RAB28. Each is linked with PFKFB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PFKFB2-to-partner and partner-to-PFKFB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf49 grouped by PFKFB2-low versus PFKFB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PFKFB2→partner) and Y-score (partner→PFKFB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C5orf49 →	+0.049	+4.152	<.001	.009	3	1
LARGE_INTESTINE	CCT4 →	+0.651	+3.067	<.001	.009	3	1
LARGE_INTESTINE	RAB28 →	+0.643	+3.067	.001	.009	3	1
LARGE_INTESTINE	USP17L3 →	+0.010	+2.560	<.001	.008	3	1
STOMACH	RTP3 →	+0.177	+3.428	.002	.008	3	1
STOMACH	SLC6A18 →	+0.073	+3.954	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

C5orf49 by PFKFB2 expression — BLOOD_Leukemia

Explore this box plot interactively →