PF4

Across TCGA pan-cancer cohorts, PF4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PF4 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PF4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PF4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

PDAC, UCEC, and LUAD are the cancer types where PF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.537	1.000	.008	10	view →
UCEC	DFS	Quartile	All	0.811	0.970	.037	8	view →
LUAD	DFS	Median	II,III,IV	0.685	0.971	.003	8	view →
HNSC	DFS	Tertile	II,III,IV	0.741	0.484	.020	7	view →
COAD	DFS	Tertile	III,IV	1.000	0.736	.029	6	view →
LSCC	DFS	Median	III,IV	0.471	1.000	.010	4	view →
GBM	DFS	Quartile	All	0.240	0.506	.018	4	view →
CCRCC	OS	Quartile	II,III,IV	0.652	0.903	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PF4–PDAC (OS)

Open the PDAC breakdown →