PF4

Across TCGA pan-cancer cohorts, PF4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PF4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PF4 RNA is repressed in tumor relative to normal tissue. In most cancer types PF4 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LUSC are the cancer types where PF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.493	<.001	10	view →
LUAD	Female	III,IV	−2.133	<.001	9	view →
LUSC	Female	II,III,IV	−2.869	<.001	8	view →
BRCA	All	II,III,IV	−0.460	<.001	6	view →
KIRC	Male	All	+0.279	.002	4	view →
COAD	All	All	+0.868	.005	3	view →
BLCA	Female	IV	−0.653	.031	2	view →
LIHC	Male	All	−0.430	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PF4–THCA

Open the THCA breakdown →