PF4

Across TCGA cell cohorts, PF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 617 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PF4-associated GO terms across cancer lineages are Negative regulation of MHC class II biosynthetic process, Zymogen activation, and Atrioventricular node cell differentiation. Each is linked with PF4 in more than 9 cancer types. Because this analysis shows association rather than direction, both PF4-to-partner and partner-to-PF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of MHC class II biosynthetic process grouped by PF4-low versus PF4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PF4→partner) and Y-score (partner→PF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of MHC class II biosynthetic process →	-0.229	-0.735	<.001	.004	3	10
LUNG_NSCLC_LUAD	Zymogen activation →	+0.117	+0.729	<.001	.001	3	4
SOFT_TISSUE	Atrioventricular node cell differentiation →	-0.071	-0.402	.002	.004	3	4
SOFT_TISSUE	Atrioventricular node cell development →	-0.071	-0.402	.002	.004	3	4
LUNG_NSCLC_LUAD	Regulation of chemokine production →	+0.053	+0.819	.004	.002	3	4
SKIN	Apoptotic signaling pathway →	+0.028	+0.175	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 617 associations by consensus.

Negative regulation of MHC class II biosynthetic process by PF4 expression — SOFT_TISSUE

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