PEX7

Across TCGA patient cohorts, PEX7 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX7-associated genes across cancer lineages are mTOR, STAT5a, and p90 RSK. Each is linked with PEX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX7-to-partner and partner-to-PEX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by PEX7-low versus PEX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX7→partner) and Y-score (partner→PEX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	+0.201	+3.000	.023	.036	3	1
UCEC	STAT5a →	+0.483	+3.000	.028	.036	3	1
UCEC	p90 RSK →	+0.237	+2.817	.023	.036	2	1
UCEC	Fibronectin →	-0.384	-3.169	.034	.020	1	1
UCEC	p62 Lck ligand →	+0.466	+3.169	.009	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

mTOR by PEX7 expression — UCEC

Explore this box plot interactively →