PEX7

Across TCGA pan-cancer cohorts, PEX7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PEX7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PEX7 RNA is repressed in tumor relative to normal tissue. In most cancer types PEX7 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where PEX7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PEX7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.930	<.001	12	view →
KIRP	Female	All	−0.966	<.001	9	view →
KICH	All	All	−0.694	<.001	9	view →
BRCA	All	II,III,IV	+0.278	.001	8	view →
BLCA	All	III,IV	+0.553	.004	6	view →
COAD	All	All	+0.450	<.001	6	view →
STAD	All	All	+0.453	.003	4	view →
LIHC	All	All	+0.274	.001	3	view →
THCA	All	All	−0.177	.023	3	view →
CHOL	All	All	+0.586	.030	2	view →
PRAD	All	All	+0.259	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PEX7–KIRC

Open the KIRC breakdown →