PEX7

Across TCGA cell cohorts, PEX7 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PEX7-associated genes across cancer lineages are OR4F5, IRS4, and CLCA2. Each is linked with PEX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX7-to-partner and partner-to-PEX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F5 grouped by PEX7-low versus PEX7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX7→partner) and Y-score (partner→PEX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F5 →	+0.036	+4.930	<.001	.001	3	1
BLOOD_Leukemia	IRS4 →	+0.032	+2.982	<.001	.007	3	1
BLOOD_Leukemia	CLCA2 →	+0.078	+3.607	.009	.004	3	1
BLOOD_Leukemia	ALLC →	+0.047	+3.714	.003	.005	3	1
BLOOD_Leukemia	GJD2 →	+0.042	+2.982	<.001	.007	3	1
BLOOD_Leukemia	NKX6-1 →	+0.678	+3.787	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR4F5 by PEX7 expression — LARGE_INTESTINE

Explore this box plot interactively →