PEX5L-AS2

Across TCGA pan-cancer cohorts, PEX5L-AS2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PEX5L-AS2 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PEX5L-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PEX5L-AS2 expression acts as an unfavorable survival marker, although some lineages such as MESO and UCS show a favorable association.

BLCA, THCA, and MESO are the cancer types where PEX5L-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.373	0.630	<.001	180	view →
THCA	DFS	Tertile	All	0.425	0.837	<.001	123	view →
MESO	OS	Tertile	All	0.566	0.292	.001	61	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	60	view →
COAD	OS	Tertile	IV	0.188	0.670	.007	45	view →
LIHC	OS	Tertile	III,IV	0.361	0.659	.011	42	view →
UCS	DFS	Tertile	II,III,IV	0.830	0.269	.011	42	view →
KIRP	OS	Tertile	II,III,IV	0.184	0.607	.009	42	view →
LAML	DFS	Tertile	All	0.882	0.368	.002	36	view →
READ	DFS	Tertile	All	0.251	0.703	.007	36	view →
BRCA	DFS	Tertile	All	0.405	0.547	.006	24	view →
THYM	DFS	Tertile	III,IV	0.214	1.000	.017	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PEX5L-AS2–BLCA (DFS)

Open the BLCA breakdown →