PEX5

Across TCGA pan-cancer cohorts, PEX5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PEX5 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PEX5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PEX5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and HNSC are the cancer types where PEX5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.995	0.576	.003	22	view →
COAD	DFS	Median	All	1.000	0.931	.025	18	view →
HNSC	DFS	Median	All	0.903	0.981	.029	4	view →
LUAD	OS	Tertile	III,IV	0.707	0.349	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PEX5–PDAC (OS)

Open the PDAC breakdown →