PEX19

Across TCGA patient cohorts, PEX19 mutation is significantly associated with the RNA expression of many other genes, with 416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX19-associated genes across cancer lineages are SNORD116-10, ZNF736P10Y, and HLA-Z. Each is linked with PEX19 in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX19-to-partner and partner-to-PEX19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-10 grouped by PEX19-low versus PEX19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX19→partner) and Y-score (partner→PEX19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD116-10 →	+0.216	+3.013	<.001	.007	3	2
UCEC	ZNF736P10Y →	+0.015	+3.736	.004	.009	3	2
UCEC	HLA-Z →	+0.520	+2.166	<.001	.001	3	2
UCEC	EI24 →	+0.458	+3.212	.007	.009	3	1
UCEC	SAP18 →	+0.326	+3.634	.004	.001	3	1
UCEC	ASTN1 →	-0.678	-2.978	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 416 associations by consensus.

SNORD116-10 by PEX19 expression — UCEC

Explore this box plot interactively →