PEX11A

Across TCGA patient cohorts, PEX11A mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX11A-associated genes across cancer lineages are eEF2, GAPDH, and GSK-3a-b_pS21_S9. Each is linked with PEX11A in more than 1 cancer types. Because this analysis shows association rather than direction, both PEX11A-to-partner and partner-to-PEX11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PEX11A-low versus PEX11A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX11A→partner) and Y-score (partner→PEX11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.470	+2.459	.006	.020	3	1
UCEC	GAPDH →	+0.660	+3.584	.010	.002	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.454	+2.179	.027	.034	3	1
UCEC	JNK2 →	+0.380	+3.009	<.001	.019	3	1
UCEC	Lck →	+0.210	+2.459	.030	.020	3	1
UCEC	N-Ras →	-0.150	-2.446	.008	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eEF2 by PEX11A expression — UCEC

Explore this box plot interactively →