PEX11A

Across TCGA pan-cancer cohorts, PEX11A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PEX11A data layer compared with 2 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PEX11A RNA is associated with better overall survival. In most high-consensus cancer types, elevated PEX11A expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

KIRC, HNSC, and OV are the cancer types where PEX11A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.728	0.532	<.001	159	view →
HNSC	DFS	Median	All	0.259	0.389	<.001	123	view →
OV	DFS	Median	All	0.591	0.490	.004	48	view →
SCLC	DFS	Quartile	All	0.358	1.000	.008	39	view →
ACC	DFS	Tertile	All	0.290	0.814	<.001	34	view →
CESC	DFS	Quartile	All	0.642	0.809	.005	34	view →
READ	DFS	Tertile	II,III,IV	0.719	0.259	.009	16	view →
KIRP	DFS	Tertile	All	0.568	0.727	.009	16	view →
LUAD	DFS	Quartile	III,IV	0.530	0.839	.007	15	view →
BRCA	DFS	Median	III,IV	0.855	0.738	.007	14	view →
STAD	DFS	Median	All	0.600	0.463	.010	13	view →
BLCA	DFS	Median	All	0.667	0.563	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PEX11A–KIRC (OS)

Open the KIRC breakdown →