PES1

Across TCGA patient cohorts, PES1 protein abundance is significantly associated with the RNA expression of many other genes, with 22,252 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PES1-associated genes across cancer lineages are TRIP13, GINS1, and MYBL2. Each is linked with PES1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PES1-to-partner and partner-to-PES1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PES1 versus TRIP13 in BRCA, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PES1→partner) and Y-score (partner→PES1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIP13 →	+1.179	+0.422	<.001	<.001	3	10
UCEC	GINS1 →	+0.912	+0.224	<.001	<.001	3	9
BRCA	MYBL2 →	+1.778	+0.387	<.001	<.001	3	9
UCEC	MCM4 →	+0.984	+0.310	<.001	<.001	3	9
BRCA	NCAPH →	+1.000	+0.362	<.001	<.001	3	9
HNSC	DKC1 →	+0.807	+0.265	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,252 associations by consensus.

PES1 vs TRIP13 — BRCA

Explore this scatter interactively →